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Sunday, June 30, 2013
Monday, June 24, 2013
Facebook Like or Share or Both on Web Page. - UK Business Forums
I would say you're best off having both.
Like simply shows the user has engaged with the site, and this activity will show up in their recent activity stream.
However, if the user chooses to Share the page, it will be posted to their wall, and probably become more visible on Facebook.
You're best off having both and giving people the choice!
__________________
Always keeping an eye open for opportunity | Fireflyer Music | SEO | Social Media | Tech Freak!
Source: http://www.ukbusinessforums.co.uk/forums/showthread.php?t=300969
Friday, June 21, 2013
Atlanta chef Ford Fry hosts fifth annual JCT. Kitchen Attack of the Killer Tomato Festival
ATLANTA (June 14, 2013) ? Join Chef Ford Fry as he hosts the fifth annual JCT. Kitchen Attack of the Killer Tomato Festival on Sunday, July 21 from 1-5 p.m. This year, more than 40 of the South?s top chefs along with 15 skilled mixologists and over 30 farmers are teaming up to create the tastiest tomato concoctions and to help raise money for Georgia Organics.
?Attack of the Killer Tomato Festival is absolutely one of my favorite events,? says Ford Fry, owner/chef of JCT. Kitchen & Bar, No. 246 and The Optimist. ?I love seeing the creativity of all the participants and I?m looking forward to seeing what this year?s crop of talent comes up with,? he adds.
Tickets are now on sale for $55 per person and $50 for Georgia Organics members and can be purchased online through Xorbia. Starting Monday, July 1, all ticket prices will increase to $70 per person. A total of 1,400 tickets are available for attendees. Last year?s festival brought in close to $26,000 for Georgia Organics.
?Here?s a recipe for success folks. Mix together the state?s best chefs, best farmers, best tomatoes, some fun music and great people, and you get the best food experience of the year: the JCT. Kitchen Attack of the Killer Tomato Festival,? says Georgia Organics Executive Director Alice Rolls. ?This event isn?t just the best party of the summer, though. It demonstrates the allure of delicious, farm-fresh food, and that?s something to celebrate!?
?The festival will once again be held at JCT. Kitchen & Bar and spread out over the pedestrian bridge that connects the two sides of Westside Provisions District.
The Attack of the Killer Tomato Festival is also an excellent opportunity for chefs and attendees alike to meet some new producers and develop longstanding relationships in order to further support the local food movement. The connection that is built between the participating farmers and restaurant professionals during this event is one that often leads to long term sourcing of locally grown produce as well as continued education for the culinary community and its diners.
?It is fitting that there is an event entirely dedicated to the preparation of tomatoes, since it is a crop that is so important not only to farmers, but chefs as well,? says Seth Hancock of Dillwood Farms, a longtime farmer participant in the JCT. Kitchen Attack of the Killer Tomato Festival who is known for providing over 20 varieties of heirloom, cherry, Sungold and slicing tomatoes and other Certified Organic vegetables in the region. ?The collaboration of farmers and chefs brings attention to local farms and farm to table restaurants, informing customers of the importance of sourcing locally grown food. Customers are able to taste the difference a locally grown tomato makes in wide variety of dishes and drink,? he adds.
Each featured chef is paired with a local farmer like Hancock to create a crowd-pleasing tomato dish for attendees to sample, while the featured mixologists listed below craft their own signature cocktails.
Participating chefs include:
Jay Swift of 4th & Swift
David Larkworthy of 5 Seasons Brewing Company
Brett Ashcraft of Abattoir
Chad Clevenger of Alma Cocina
Andy Carson and Carla Tomasko of Bacchanalia
Lance Gummere of Bantam + Biddy
Bruce Logue of BoccaLupo
Suzanne Vizethann of Buttermilk Kitchen
Carvel Grant Gould of Canoe
Asha Gomez of Cardamom Hill
Delia Champion of Delia?s Chicken Sausage Stand
Ryan Smith of Empire State South
Whitney Otawka of Farm 255
Dan Latham and Cameron Thompson of Farm Burger
Todd Immel of Floataway Caf?
Kevin Gillespie of Gunshow
E.J. Hodgkinson of JCT. Kitchen & Bar
Taria Camerino of JCT. Kitchen & Bar, King + Duke, No. 246 and The Optimist
Joe Schafer of King + Duke
Nick Carse of King of Pops
Brent Banda of La Tavola Trattoria
Eric Ottensmeyer of Leon?s Full Service
Chris Hall of Local Three
Jeremiah Bacon of The Macintosh (in Charleston, SC)
Steven Satterfield of Miller Union
Drew Belline of No. 246
Andrew Smith and Scotley Innis of Ormsby?s
Adam Evans of The Optimist and Oyster Bar at The Optimist
Robert Gerstenecker of Park 75
Nick Rutherford and Molly Gunn of The Porter
Kevin Rathbun of Rathbun?s, Kevin Rathbun Steak, Krog Bar and KR SteakBar
Ron Eyester of Rosebud and The Family Dog
Scott Serpas of Serpas True Food
Drew Van Leuvan of Seven Lamps
Jenny Levison and Jessica Hanners of Souper Jenny
Cooper Miller of Southbound
Robert Elliot of Sprig *?2012 Best Booth?
Eddie Hernandez of Taqueria del Sol
Tyler Williams of Woodfire Grill
?
Participating mixologists include:
Kevin Bragg of 4th& Swift
Ryan McLaughlin and Heather Miller of Abattoir
Kellie Thorn of Empire State South
Jerry Slater and Callie Schlosser of H. Harper Station
Eduardo Guzman of JCT. Kitchen & Bar and The Optimist
Miles Macquarrie of Leon?s Full Service *?2012 People?s Choice for Best Tasting Cocktail?
Kevin Ryan of Local Three
Stuart White of Miller Union
Paul Calvert of Paper Plane and Victory Sandwich Bar *?2012 Best Tasting Cocktail?
Nate Shuman of Proof and Provision
Andy Minchow of Ration & Dram
Jeff Jackson of Rosebud
Arianne Fielder of Seven Lamps
Navarro Carr of Sound Table
Brian Stanger of Woodfire Grill
High-profile judges including Garden & Gun Deputy Editor Dave Mezz, Food & Wine Associate Food Editor Daniel Gritzer, Esquire restaurant features writer?John Mariani and James Beard Award-winning authors Matt and Ted Lee, are choosing the best dish, best beverage and best table decorations during the event. Food writer, stylist and photographer Angie Mosier and registered dietician, author and food journalist Carolyn O?Neil are returning as co-masters of ceremonies, and guests can enjoy live performances from The Spazmatics and local chef band Five Bone Rack. Special guest David Miller, the actor who played Mason Dixon in the original ?Attack of the Killer Tomatoes? movie, is returning this year to present the awards to winners. Atlanta Foods International, Crop Organic Vodka, Farmer?s Botanical Small Batch Organic Gin, Georgia Crown Distributing Co., The Icebox, Melwood Springs, Ole Smoky Moonshine, paQui Tequila, Scoutmob, Springer Mountain Farms, TriMark South, Wild Heaven Craft Beers and Westside Provisions District are event sponsors. For more information, visit killertomatofest.com.
Georgia Organics is a member supported nonprofit connecting organic food from Georgia farms to Georgia families. The organization is increasing the number of organic farmers in rural and urban areas, increasing the number of children participating in farm to school programs, and increasing the number of Georgians eating organically grown, local food. These links improve public health, support local farmers and strengthen Georgia?s environment. For more information on Georgia Organics, visit georgiaorganics.org or call 678-702-0400. Georgia Organics office is located at 200-A Ottley Drive in Atlanta.
JCT. Kitchen & Bar is located in Atlanta?s Westside Urban Market at 1198 Howell Mill Road, Suite 18. To make a reservation, call JCT. Kitchen & Bar at 404-355-2252 or visit jctkitchen.com.
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Thursday, June 20, 2013
The Peres Parade: A Macher's Paradise
The Israeli President's Conference, hosted by Shimon Peres?this year, in honor of his 90th birthday?is a Jewish macher's?paradise. It's where you rub shoulders with the big boys and enjoy highbrow ambiance. A few minutes ago, Robert DeNiro walked by me, entourage in tow. Earlier this morning, I watched Tony Blair and Rahm Emmanuel speak on a panel with Shimon Peres, and Bill Clinton tear up as he watched a tribute video dedicated to his work in the Middle East just before he was handed the President's Award, one of the main events here.
This has been the story of the conference whose theme was "Tomorrow"?a half million dollars to Clinton's Foundation for a couple of emotional speeches and a statement ("you are the world's social Einstein") Barbra Streisand singing "Avinu Malkeinu", and an "intimate photo essay" with Shimon Peres. The New York Times quoted Tony Blair as saying, "We in Britain have our queen, and you have your Shimon Peres." And just as the Queen's Jubilee embodies, in some ways, the rarified essence of what the British Empire stands (or stood) for?a glorious and regal history, an intellectually rigorous tradition?the President's Conference shows an imagined ideal Israel hopes to represent: an immaculate, hi-tech, cutting-edge, air conditioned hub where everyone pays for lunch.
U.S. singer Barbra Streisand, former U.S. president Bill Clinton, Israeli President Shimon Peres and Israeli Prime Minister Benjamin Netanyahu attend Peres's 90th birthday celebrations in Jerusalem, on June 18, 2013. (Jim Hollander / AFP / Getty Images)
And it is truly amazing. I managed, in the span of an hour, to interview two giants of the American Jewish conversation on Israel (although had I wanted to interview any number of Nobel Prize laureates, artists, or past heads of CEOs of tech companies, I probably could have done that, too). I interviewed the Anti-Defamation League?s Abe Foxman, who told me that he's been to every President's Conference, and that this one was the most political. His main message was about the conference's lack of Palestinian voices: "I think it?s wonderful that Tony Blair and Rahm Emmanuel want to be machatonim ("in laws") to peace?but you can't just go with the groom [Israel], you need the bride [the Palestinians]? I get the sense that we're talking to ourselves"?which I took as a fair point. And a few minutes later I spoke with the Jewish Center for Public Affairs's Dore Gold. Our conversation spanned Peter Beinart's The Crisis of Zionism, the U.N.'s failure in Rwanda (Clinton had referenced the issue in his speech, likely because Rwandan President Paul Kagame had been sitting in the front row) and what Gold's "Defensible Borders" meant for a contiguous Palestinian state. I've never done an interview where access was so easily granted.
The speakers, their speeches, the machers, and the mingling made a serious impression on the young people at the conference. I spoke to a number of ambitious Ivy League college students who are in Israel on summer internships through a program called Birthright "EXCEL." They told me (none agreed to be quoted by name) how the "great speakers" and "great speeches" made them feel like they were "learning a lot" from an "amazing number of diverse and incredibly accomplished and intelligent speeches." In short: they were awed.
The slightly older, entrepreneurial generation?those who had already been through this before?were more skeptical. Sam Chester, an American from Minneapolis who immigrated to Israel in 2009, came to Peres's 86th birthday party four years ago. He put it this way:
This is one of those conferences where the real action happens in the hallway?and they've overloaded with big name speakers, but no one can go from panel to panel from morning to night. I wonder to what extent they do this on purpose? I went to this conference when he was turning 86, and there's a certain limit. This is a little overboard? How much does this conference want to be about celebrating a man and how much does it want to be about the broader Israel innovations looking to the future?
It's not that the conference is devoid of substance. It's not. In fact, Sam described the two-and-a-half-day event as a combination of global development and innovation conference (like a "mini-Davos") and a Jewish World get-together (akin to the General Assembly). And it did those things well. It was light on Middle East issues, he said, which is strange because that's what Peres is known for. He established the Peres Center for Peace. He wrote the book, The New Middle East. Yet there was only one panel on "Israel and a Changing Middle East" and close to zero Arab names on the lineup. Sure, politics don't have to consume Israel, but it might have been wise to ease up on the global tomorrow and actually focus on today?here, in the Middle East.
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GOP aide goes on popsicle-fueled right-wing publicity stunt in favor of cutting food stamps
Apparently stung by the Democratic pushback against House Republican dreams of slashing the Supplemental Nutrition Assistance Program by $21 billion over 10 years, Rep. Steve Stockman is lashing out. Where two dozen Democratic members of the House did a SNAP challenge themselves, eating on the average food stamp budget for a week, Stockman had an aide do the challenge and then announce that it's a breeze, no problem, we can totally cut the program.
Question: If it's so easy to eat on less than a SNAP budget, proving that cuts are totally warranted, why aren't Republican members of the House doing the challenge en masse? Why is it left to one staffer to make this point? I mean, really, dozens of members of Congress do the challenge and say it's hard, to say nothing of all the clergy and others who've participated and say the same. To say nothing of all the people who actually live on this budget and it's miserable and difficult.
Well, let's take a look at what Stockman communications director and master of the universe Donny Ferguson bought as his entire food supply for a week:
For $21.55 Ferguson purchased at Dollar Tree:So he's got a lot of cereal for breakfast, and he can have peanut butter and jelly sandwiches for lunch, along with maybe some applesauce and fruit drink. For dinner, it looks like he's eating spaghetti for a couple nights and otherwise eating beans and rice. Also popsicles and cookies. Healthy diet, there! And such a varied menu at dinner. Perhaps Ferguson isn't aware that the definition of low food security is "reports of reduced quality, variety, or desirability of diet. Little or no indication of reduced food intake." Exactly the diet he's reporting, in other words: fruits and vegetables only in the form of grape jelly, pasta sauce, and applesauce, heavily dependent on root beer and cookies and sugary cereal for calories, and beans and rice night after night for dinner. Not to mention the increased health care costs we can expect to see as a result of people living on diets like this and developing diabetes, hypertension, and a series of other health problems.
Two boxes of Honeycomb cereal
Three cans of red beans and rice
Jar of peanut butter
Bottle of grape jelly
Loaf of whole wheat bread
Two cans of refried beans
Box of spaghetti
Large can of pasta sauce
Two liters of root beer
Large box of popsicles
24 servings of Wyler?s fruit drink mix
Eight cups of applesauce
Bag of pinto beans
Bag of rice
Bag of cookiesFor $6.03 at the Shoppers Food Warehouse next door Ferguson bought a gallon of milk and a box of maple and brown sugar oatmeal.
If having food stamp recipients actually starving wasn't a goal for Republicans, they'd see this shopping list for what it is: an argument in favor of increasing SNAP benefits. But to Stockman and Ferguson, the SNAP challenge was nothing but "a left-wing publicity stunt," to be countered with a right-wing publicity stunt. And you know, it kind of is a left-wing publicity stunt?one that says "you can ignore all the people who live on this budget day in, day out. Can you ignore members of Congress and clergy and community leaders?" It's telling that the counterpart right-wing publicity stunt says "let them live on cookies and grape jelly, let's cut more."
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Monday, June 17, 2013
Media study: more pro views on same-sex marriage
NEW YORK (AP) ? Around the time the U.S. Supreme Court was considering the same-sex marriage issue, news reports had more comments from supporters than opponents, a study released Monday concluded.
The Pew Research Center's Project for Excellence in Journalism looked at nearly 500 stories on the topic over a two-month period that began just before the court started hearings in March on legalizing same-sex marriage. By a 5-to-1 margin, the stories with statements in support of legalization outweighed those dominated by opponents' views.
But Pew said the results were in large part because many of the stories were about polls showing societal attitudes swiftly moving toward support for gay marriage, or about politicians announcing their support. A disciplined approach by supporters was also a factor, Pew found.
"Certainly it is evident in these findings the degree to which supporters of same-sex marriage were largely successful in getting their message out in a clear way, a consistent way, across a wide swath of the news media," said Amy Mitchell, acting director of the project.
Supporters primarily defined the issue as one of civil rights. At the same time, Pew said, opponents haven't coalesced behind a single argument but instead posed many: homosexuality is immoral; same-sex marriage hurts families or society; civil unions are good enough; or government should not impose a new definition of marriage.
The findings were consistent across different media. For instance, 43 percent of newspaper stories showed at least a 2-to-1 margin of pro views to con, 8 percent were dominated by opponents and 48 percent were largely neutral, Pew said. The proportions of supporter-opponent content in stories for all three cable news networks were similar.
Twenty-nine percent of the stories by Fox News Channel, which appeals to conservatives, were dominated by supporters, 8 percent by opponents and 63 percent had about the same pro and con views, Pew said.
While the nation's attitudes have been shifting, a recent Pew Research Center survey found that 51 percent of the public favored legalizing same-sex marriage and 42 percent opposed it.
Pew found that Twitter postings were more closely aligned with public opinion than news coverage. Tweets were about the same between positive and negative, with the greater proportion of negative comments coming directly after the Supreme Court began hearing arguments.
Mitchell demurred when asked whether the study provided evidence for conservatives who believe that news media opinions tilt left.
"I don't think the study can necessarily speak to that one way or another," she said.
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Good 'Game of Thrones' dads rarer than dragons
TV 
3 hours ago
HBO
Tywin Lannister (Charles Dance), Jaime Lannister (Nikolaj Coster-Waldau) and Ned Stark (Sean Bean) are all fathers on "Game of Thrones," but they're not all great.
Dragons. Swords. Battles. Adventures. Castles. "Game of Thrones" has plenty of these, but it also has a lot of fathers. And like the other characters that fill out the series, the dads are human -- in other words, they're flawed.
No one's perfect no matter how hard they might try, but in the world of "Thrones," it's obvious that some papas try a heck of a lot harder than others to be as close to being the perfect dad as possible. So as we raise a sword in honor of all dads, we take a look at the fathers of "GoT" to see who deserves an extra hug and kiss on the cheek.
The good
It's a little sad to say, but there are really only two truly good dads on "Game of Thrones": Ned Stark and Davos Seaworth, and papas out there can certainly look to these two as examples of how to parent.
Both men clearly love their children and have their best interests at heart. The illiterate Onion Knight was born incredibly poor, and worked as a smuggler who slowly rose to the ranks of King Stannis' Hand by being loyal and honest -- good virtues, both. Everything he did, he did so that his sons could have a better life than he had, and become the educated lords he hopes for them to be.
As for Ned Stark, in a world where sons are valued over daughters, he loved all of his children equally regardless of their gender, whether they were trueborn or not. He accepted his kids as they were and encouraged them to follow their passions. (How many dads in Westeros would let their little girls learn the art of sword fighting over embroidery and songs?) When unpleasant life lessons came up, he didn't shy away. And perhaps most important, through his actions, he taught them that it is always best to do what is right and honorable -- even if that meant literally losing one's head.
The mediocre
Forgot Stannis Baratheon is a daddy, did you? It's pretty easy to do, seeing as how daughter Shireen is hidden away. (Is it because of her greyscale? Teach her that looks aren't everything!) But it does appear that he loves the little girl, despite rarely seeing her. And don't forget he fathered the shadow assassin -- thanks to Melisandre -- a creature that soon killed his brother Renley.
The bad
It almost seems silly to count Robert Baratheon and Jaime Lannister as dads. Yes, they fathered children -- a lot of children, in King Robert's case -- but that was about it. Neither man actually parented much. (Though we suppose Jaime had a good excuse for not stepping up, seeing as how incest and treason are frowned upon.) When the king did do his fatherly duties, it was obvious he'd rather be off drinking and hunting. He didn't bother to teach "his" royal kids right from wrong, and left the realm with Mad King Joffrey upon his death. And "Uncle" Jaime never had much to do with his "niece" and "nephews" at all.
Then there's Randyll Tarly. Sure, viewers haven't met him, but they've heard of him through son Sam, a member of the Night's Watch. And it's Sam's presence on The Wall that makes Lord Tarly such a bad dad. As the well-read crow tells Jon Snow in season one, the mighty lord was disgusted that his firstborn son was more interested in books than manlier pastimes, and gave him a choice between The Wall or a "hunting accident." Way to love your kid unconditionally.
Bad dads can't be discussed without a mention of Tywin Lannister, the biggest lion of Casterly Rock. Some might argue he's beyond bad, that he's the baddest of the bad, but hear us out about why he's merely just plain bad. Yes, he's a power-hungry lord who very obviously plays favorites with his children. (Is your name Jaime? No? Sorry, he doesn't really care about you.) But everything he does, he does to secure power, wealth and glory for Lannisters. ALL Lannisters. That includes Tyrion, whom he very clearly despises. And as much as he might hate his youngest son, he not only let the child live (albeit blaming him for his beloved wife's death as she birthed Tyrion), but let him live as a lord. That's got to count for something.
The worst
Yes, there really are worse dads than Tywin on "Game of Thrones," and their names are Balon Greyjoy and Craster. (You nearly forgot about them, didn't you?)
Balon at first didn't seem too terrible. He obviously loves and supports his daughter, Yara, who is anything but a traditional lady. But the same affection was denied son Theon, whom he considers more Stark than Greyjoy despite the young man's sacking of Winterfell to regain his father's love. Even worse, when Ramsay Bolton sent captive Theon's manhood back to his papa, Balon declared that since his son can no longer further the Greyjoy line, he was useless. Harsh.
As bad a dad as the Lord of Pyke is, Craster could beat him for title of the worst. The wildling fathers daughters of his wives, and when the girls are old enough, marries them and sires more daughters to repeat the endless cycle. As for the boys he fathers, they face an even more dire future: Craster leaves them in the snowy woods for the White Walkers to take. It doesn't get much worse than that.
Source: http://www.today.com/entertainment/good-dads-are-rarer-dragons-game-thrones-6C10315943
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Sunday, June 16, 2013
'Chase and run' cell movement mechanism explains process of metastasis
![[ Back to EurekAlert! ]](http://www.eurekalert.org/images/back2e.gif){kind=small}
Public release date: 16-Jun-2013[ | E-mail |
Share ] Contact: Clare Ryan
clare.ryan@ucl.ac.uk
44-020-310-83846
University College London
A mechanism that cells use to group together and move around the body called 'chase and run' - has been described for the first time by scientists at UCL.
Published in Nature Cell Biology, the new study focuses on the process that occurs when cancer cells interact with healthy cells in order to migrate around the body during metastasis. Scientists know that cancer cells recruit healthy cells and use them to travel long distances, but how this process takes place and how it could be controlled to design new therapies against cancer remains unknown.
Now, using embryonic cells called 'neural crest cells' (which are similar to cancer cells in term of their invasive behaviour) and placode cells which are the precursors for cranial nerves (the equivalent to healthy cells) researchers at UCL have started to unravel this process.
They have found that when neural crest cells are put next to placode cells they undergo a dramatic transformation and start 'chasing' the placode cells. At the same time placode cells exhibite 'escape' behaviour when contacted by neural crest cells. The chasing behavior depends on the production of small chemical molecules by the placode cells that attracts neural crest cells toward them.
The authors of the study are confident that the process whereby cancer cells attached to healthy cells in order to migrate around the body is comparable. Healthy cells of the body try to escape from tumor cells, but are followed by malignant cells because the healthy cells produce an attractant for the cancer cells.
Dr Roberto Mayor, UCL Department of Cell and Developmental Biology and lead author of the research, said, "We use the analogy of the donkey and the carrot to explain this behaviour: the donkey follows the carrot, but the carrot moves away when approached by the donkey. Similarly the neural crest cells follow the placode cells, but placode cells move away when touched by neural crest cells."
"The findings suggest an alternative way in which cancer treatments might work in the future if therapies can be targeted at the process of interaction between malignant and healthy cells to stop cancer cells from spreading and causing secondary tumours."
"Most cancer deaths are not due to the formation of the primary tumor, instead people die from secondary tumors originating from the first malignant cells, which are able to travel and colonize vital organs of the body such as the lungs or the brain."
###
The work was funded by the Medical Research Council and the Wellcome Trust.
Notes for Editors
1. For more information or to interview Dr Roberto Mayor, please contact Clare Ryan in the UCL Media Relations Office on tel: +44 (0)20 7679 9726, mobile: +44 07747 565 056, out of hours +44 (0)7917 271 364, e-mail: clare.ryan@ucl.ac.uk.
2. 'Chase-and-run between adjacent cell populations promotes directional collective migration' is published in the journal Nature Cell Biology. Journalists can obtain copies of the paper by contacting UCL Media Relations.
3. Images of the neural crest cells are also available to journalists by contacting UCL Media Relations.
About UCL (University College London)
Founded in 1826, UCL was the first English university established after Oxford and Cambridge, the first to admit students regardless of race, class, religion or gender and the first to provide systematic teaching of law, architecture and medicine. We are among the world's top universities, as reflected by our performance in a range of international rankings and tables. According to the Thomson Scientific Citation Index, UCL is the second most highly cited European university and the 15th most highly cited in the world. UCL has nearly 25,000 students from 150 countries and more than 9,000 employees, of whom one third are from outside the UK. The university is based in Bloomsbury in the heart of London, but also has two international campuses UCL Australia and UCL Qatar. Our annual income is more than 800 million. http://www.ucl.ac.uk | Follow us on Twitter @uclnews | Watch our YouTube channel YouTube.com/UCLTV
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 16-Jun-2013[ | E-mail |
Share ] Contact: Clare Ryan
clare.ryan@ucl.ac.uk
44-020-310-83846
University College London
A mechanism that cells use to group together and move around the body called 'chase and run' - has been described for the first time by scientists at UCL.
Published in Nature Cell Biology, the new study focuses on the process that occurs when cancer cells interact with healthy cells in order to migrate around the body during metastasis. Scientists know that cancer cells recruit healthy cells and use them to travel long distances, but how this process takes place and how it could be controlled to design new therapies against cancer remains unknown.
Now, using embryonic cells called 'neural crest cells' (which are similar to cancer cells in term of their invasive behaviour) and placode cells which are the precursors for cranial nerves (the equivalent to healthy cells) researchers at UCL have started to unravel this process.
They have found that when neural crest cells are put next to placode cells they undergo a dramatic transformation and start 'chasing' the placode cells. At the same time placode cells exhibite 'escape' behaviour when contacted by neural crest cells. The chasing behavior depends on the production of small chemical molecules by the placode cells that attracts neural crest cells toward them.
The authors of the study are confident that the process whereby cancer cells attached to healthy cells in order to migrate around the body is comparable. Healthy cells of the body try to escape from tumor cells, but are followed by malignant cells because the healthy cells produce an attractant for the cancer cells.
Dr Roberto Mayor, UCL Department of Cell and Developmental Biology and lead author of the research, said, "We use the analogy of the donkey and the carrot to explain this behaviour: the donkey follows the carrot, but the carrot moves away when approached by the donkey. Similarly the neural crest cells follow the placode cells, but placode cells move away when touched by neural crest cells."
"The findings suggest an alternative way in which cancer treatments might work in the future if therapies can be targeted at the process of interaction between malignant and healthy cells to stop cancer cells from spreading and causing secondary tumours."
"Most cancer deaths are not due to the formation of the primary tumor, instead people die from secondary tumors originating from the first malignant cells, which are able to travel and colonize vital organs of the body such as the lungs or the brain."
###
The work was funded by the Medical Research Council and the Wellcome Trust.
Notes for Editors
1. For more information or to interview Dr Roberto Mayor, please contact Clare Ryan in the UCL Media Relations Office on tel: +44 (0)20 7679 9726, mobile: +44 07747 565 056, out of hours +44 (0)7917 271 364, e-mail: clare.ryan@ucl.ac.uk.
2. 'Chase-and-run between adjacent cell populations promotes directional collective migration' is published in the journal Nature Cell Biology. Journalists can obtain copies of the paper by contacting UCL Media Relations.
3. Images of the neural crest cells are also available to journalists by contacting UCL Media Relations.
About UCL (University College London)
Founded in 1826, UCL was the first English university established after Oxford and Cambridge, the first to admit students regardless of race, class, religion or gender and the first to provide systematic teaching of law, architecture and medicine. We are among the world's top universities, as reflected by our performance in a range of international rankings and tables. According to the Thomson Scientific Citation Index, UCL is the second most highly cited European university and the 15th most highly cited in the world. UCL has nearly 25,000 students from 150 countries and more than 9,000 employees, of whom one third are from outside the UK. The university is based in Bloomsbury in the heart of London, but also has two international campuses UCL Australia and UCL Qatar. Our annual income is more than 800 million. http://www.ucl.ac.uk | Follow us on Twitter @uclnews | Watch our YouTube channel YouTube.com/UCLTV
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2013-06/ucl-car061313.php
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Tuesday, June 11, 2013
Israel signals readiness to limit settlement building for peace
JERUSALEM (Reuters) - Prime Minister Benjamin Netanyahu hinted on Monday that Israel was ready to confine Jewish settlement expansion to the blocs of occupied territory it wants to keep under any peace deal with the Palestinians, in a nod to U.S. efforts to revive stalled negotiations.
Settlement construction was cited as a key reason for the breakdown of U.S.-sponsored peace talks in 2010, and a stumbling block to Secretary of State John Kerry's latest efforts to revive negotiations towards founding a Palestinian state in land Israel captured in the 1967 Middle East war.
Netanyahu told Parliament's Foreign Affairs and Defense Committee that he wanted to resume peace talks, but that construction in the settlements in the West Bank would continue, "and continues today".
He added, though, that "we have to be smart about it, not just correct".
"Settlement in the blocs wouldn't substantively change the ability to reach an agreement," he said, referring to several clusters of enclaves where a majority of settlers live.
Netanyahu spoke behind closed doors and officials released some of his remarks in a statement issued later to reporters.
Israel has long said that under any peace agreement it intends to keep its largest settler enclaves built in Ariel, near the Palestinian city of Nablus, in Gush Etzion in the Bethlehem area, and in the Jerusalem area.
Palestinian President Mahmoud Abbas has so far linked a resumption of peace talks to a total freeze in settlement construction, which Palestinians see as establishing facts on the ground that deny them land they need for a viable state.
One of Netanyahu's senior political partners, member of parliament Avigdor Lieberman, told Army Radio Israel was already observing a break in construction in East Jerusalem.
"One should view this as a temporary hiatus," the former foreign minister said. He added: "We have an interest in Kerry succeeding."
Israel captured East Jerusalem in the same war in which it took the West Bank, but annexed the city as part of its capital in a move never recognized internationally. Palestinians want East Jerusalem to be capital of their future state.
Since taking office in February, Kerry has visited Israel and the Palestinian territories four times in his drive to win the agreement of the sides to renew negotiations.
(Writing by Allyn Fisher-Ilan; Editing by Mark Trevelyan)
Source: http://news.yahoo.com/israel-signals-readiness-limit-settlement-building-peace-001352431.html
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Focus on Your Readers, Not Your Writing Expertise | Writing and ...
Why is it important for writers to focus on their readers, rather than how expertly they write?
Written communication to a large extent is one dimensional. All the reader has is what?s in front of them.
But when we talk to people, there are?auditory and visual clues?that help convey our message. Listeners ?read? our facial expressions and watch our body language to improve their understanding of what we?re saying. They can?see?the twinkle in your eye when you make a facetious comment ? they know not to take you seriously. But if you were to write that comment, can you be sure it will not be taken as an insult?
Listeners can?hear?the inflections and changing tones in your voice. A question is recognised by the rising inflection at the end of the sentence. In its written form, it would appear as?Do you want me to do that??If I wanted to emphasise?me, I?d say that word a little more firmly or loudly? but how do you make that distinction when you write? You could use bold, hoping that the reader will notice that the word is bold and that they know what it suggests.
Perhaps the greatest advantage oral communication has over writing is the opportunity for feedback. Listeners can ask questions, make comments, paraphrase back to you? and it happens immediately. Both parties can complete the conversation feeling fairly confident that the message has been understood.
Unfortunately, we don?t necessarily have that same level of confidence when writing. Yes, readers can contact you with their questions or comments, but that doesn?t happen very often in today?s fast-paced life.
So how can we by-pass those potential hurdles?
?
- Know your message. Be sure you know exactly what you want your readers to know, understand or do by the time they?ve finished reading. It?s the same technique marketing mentors teach us: your call to action, your 30-second spiel, your summary. Try out versions until you?re sure you know your message is saying?exactly?what you want it to say.
- Know your readers.?Have a mental picture of your reader, give her a name, understand what sort of writing she?ll relate to, understand what she?d like to know. Decide what language style (formal, informal, chatty, serious, light-hearted) will be most appropriate. How many specialised terms or abbreviations can you use, will you need to explain them, how? Could a graphic (table, illustration, graph, photo) be used instead of a chunk of text? You?ll certainly gain focus and clarity when you answer these question (and any others that help you understand your reader)?before?you begin to plan your writing.
- Review your writing before you publish.?When you?ve finished writing, put it to one side for as long as possible, then come back to it with fresh eyes. You?ll see what you have written, not what you meant to write. Read out loud ? hearing what you?ve written will alert you to mistakes or clumsy constructions. And if you need to take a breath before you reach the end of a sentence, it would probably benefit from being turned into two shorter sentences. If possible, print out your document ? reading it in a format often lets mistakes jump out at you. Have a trusted colleague (preferably someone who?s not particularly familiar with the subject) review and comment.
?
As you write, try to keep your reader at the front of your mind.
As you review, try to step into your reader?s shoes and read your article through their eyes.
Your readers will thank you for your focus on them and for making your article clear, engaging and sharp.
Desolie Page is an accredited editor (Institute of Professional Editors Australia) and owner of Perfect Pages.
I give you the confidence that your technical and business writing is clear, engaging and sharp.
When you need help with editing, proofreading, or copywriting, contact me to find out how I can help. I work with you to understand your audience, and use clear, precise language to get your message across.
I?ve developed and present workshops for business and technical writers, an excellent way to sharpen your writing.
All aspects of my work focus on the use of plain English and on ways to increase the readability of your document (including formatting) so that your readers will enjoy reading what you?ve written while clearly understanding your message.
I?m always delighted when my clients tell me how much they?ve learnt from my input into their writing.
Find out more about Perfect Pages by visiting?http://perfectpages.net.au
Source: http://www.writingspeakingtips.com/focus-on-your-readers-not-your-writing-expertise/
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Saturday, June 8, 2013
Factbox: Likely candidates to replace Bernanke at Fed in 2014
(Reuters) - Federal Reserve Chairman Ben Bernanke is widely expected to step down when his second term at the helm of the U.S. central bank expires on January 31, 2014.
If history is any guide, President Barack Obama will pick a candidate to succeed the one-time Princeton University professor sometime during the summer, allowing ample time for the Senate to consider the nominee before a final confirming vote.
Here is a quick look at the likely leading choices:
JANET YELLEN
Yellen, 66, has been Fed vice chair since 2010. She has been a forceful advocate of the aggressive steps taken under Bernanke to spur U.S. economic growth, earning her a reputation as a policy "dove" who would tolerate a bit more inflation to drive down unemployment that she deemed too high.
If picked to succeed Bernanke, she would become the 100-year-old central bank's first female chief. Prior to her current post, Yellen was president of the Federal Reserve Bank of San Francisco. She also served as chairman of the White House Council of Economics Advisors under President Bill Clinton, and was a Fed Board governor in Washington from 1994 to 1997.
A former professor at the University of California, Berkeley, Yellen is a highly respected economist with a high standing among other academics. She began her career as an assistant professor at Harvard in the early 1970s before shifting over to the Fed.
LAWRENCE SUMMERS
Summers, 58, is an eminent Harvard economist who was Obama's first National Economic Council director, a post within the president's inner circle. He also served President Bill Clinton as Treasury secretary and before that in other senior Treasury posts.
Viewed as brilliant but prickly, Summers was a full Harvard professor by the age of 28 and was later university president. But his abrasive style made enemies, and he resigned as president in 2006. That said, his expertise, professional accomplishments and his service to Obama are likely to earn him serious consideration for the top Fed post.
Since leaving the Obama White House in 2010, Summers has returned to teaching at Harvard and has also joined the board of several private companies and become a part-time special adviser to venture capital firm Andreessen Horowitz. He also worked for hedge fund D.E. Shaw from 2006 until November 2008, when he was picked by Obama to run the NEC.
TIMOTHY GEITHNER
Timothy Geithner, 51, was Obama's first-term Treasury secretary. He is also seen as a possible contender for the nomination, but has said that he does not want the job.
If Geithner could be persuaded to change his mind, his track-record is compelling. Before he was tapped for Treasury, he was already at the center of the nation's emergency response to the financial crisis as head of the New York Federal Reserve Bank. He also served in senior posts in the Clinton Treasury and at the International Monetary Fund.
Geithner is currently writing a book.
ROGER FERGUSON
Ferguson, 61, is currently chief executive of TIAA-CREF, which manages retirement funds for many of the nation's schools and hospitals. A Harvard-educated economist and lawyer who was Fed vice chairman from 1999 to 2006, Ferguson was highly respected within the Fed as a very smart and thorough policymaker. His appointment would be historical: it would make him the first African-American to chair the U.S. central bank.
DONALD KOHN
A lifetime Fed insider who retired as vice chairman in 2010 after 40 years at the central bank, Kohn is a hugely respected economist who would be viewed as a safe choice to lead the Fed, if he could be persuaded to return to public office.
Before taking a Fed board seat, Kohn, 70, was a top staff lieutenant to then-chairman Alan Greenspan. He is now an external member of the Bank of England's Financial Policy Committee, which sets broad guidelines for the U.K. financial system, and a senior fellow at the Brookings Institution, a Washington think tank.
(Reporting by Alister Bull; Editing by Tim Dobbyn)
Source: http://news.yahoo.com/factbox-likely-candidates-replace-bernanke-fed-2014-051119916.html
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Wednesday, June 5, 2013
Twitter back online after brief outage
Twitter 
6 hours ago
Regis Duvignau / Reuters
Twitter was down for about a half-hour for an unknown number of users on Monday after a glitch during a "routine change."
The microblogging service said in a short post that it had rolled back the changes, fixing the issues though some users experienced delays in getting updated tweets.
Earlier on Monday, users trying to click on trending topics and other posts received an error message that began with "something is technically wrong."
"Due to an error in a routine change, Twitter was not available from 1:08pm PDT to 1:33pm PDT. We rolled back the erroneous change as soon as we identified the issue," the company said.
Twitter's phenomenal growth since its 2006 birth means it has struggled to handle an ever-rising volume of tweets. It currently claims more than 200 million users, generating about 400 million tweets ? or 140-character messages ? daily.
Since enduring repeated criticism about its infamous "fail whale" outage icon in its early years, the microblogging service has devoted considerable resources to improving reliability, in a move to project itself as a mature, polished brand.
This story was updated at 6:20 p.m. ET.
Copyright 2013 Thomson Reuters.
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Monday, June 3, 2013
Actor Matt Smith leaving 'Doctor Who'
7 hours ago
BBC
The BBC has announced that after four years as Doctor Who, Matt Smith is leaving the role at the end of this year.
The doctor is clocking out. Matt Smith, who has played the titular character in BBC's "Doctor Who" since 2010, will be exiting the show this year, the network announced. His final TARDIS bow will be the 50th anniversary special in November, however BBC revealed that he will make an appearance in the Christmas special, as well.
Smith wrote on BBC's "Doctor Who" website about his departure:
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"'Doctor Who' has been the most brilliant experience for me as an actor and a bloke, and that largely is down to the cast, crew and fans of the show. I'm incredibly grateful to all the cast and crew who work tirelessly every day, to realise all the elements of the show and deliver 'Doctor Who' to the audience. Many of them have become good friends and I'm incredibly proud of what we have achieved over the last four years.
"The fans of 'Doctor Who' around the world are unlike any other; they dress up, shout louder, know more about the history of the show (and speculate more about the future of the show) in a way that I've never seen before, your dedication is truly remarkable. Thank you so very much for supporting my incarnation of the Time Lord, number Eleven, who I might add is not done yet, I'm back for the 50th anniversary and the Christmas special!"
PHOTOS: TV's big moments of the week
To read more from Smith, and to hear from writer and executive producer Steven Moffat, check out their statement on the BBC website.
Source: http://www.today.com/entertainment/actor-matt-smith-leaving-doctor-who-6C10167523
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